On Monday, February 1st, 2016, ICAN is organizing an international half-day seminar focused on cardiac repair and on adipose tissue dynamics.
Prof. Karine Clément and Prof. Jean-Sebastien Hulot have invited expert speakers from Israel and the USA to present three talks varying from exosome crosstalk, to obesity stress networks, and lifestyle interventions affecting adipose tissue.
11am – 12pm
Cellular Crosstalk to Mend a Broken Heart: Exosomes in Cardiac Repair
Prof. Susmita SAHOO
Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, USA
Exosomes are naturally secreted nanovesicles that mediate stem cell-induced cardiac repair via transferring their unique repertoire of miRNAs inducing proliferation, angiogenesis and cardiac function. Cell-free exosomes can be a vector for delivering miRNAs, genes, and even viruses and can be a suitable replacement to cellular and gene therapies for cardiac repair and regeneration.
Susmita Sahoo, PhD, is an assistant professor at the Icahn School of Medicine at Mount Sinai, New York. She completed her education and training at the Indian Institute of Technology, Mumbai and at Northwestern University, Chicago. She has established a new line of research in the field of ‘Cardiovascular Regenerative Medicine’ to study miniature vesicles secreted by cells called exosomes and their role in cardiac regeneration. Currently, with the help of NIH and AHA-funded research, Dr. Sahoo’s laboratory investigates cellular, tissue and organ level microcommunication mechanisms that can contribute to new therapeutic approaches to repair and regenerate the heart.
1pm – 1:45pm
Adipose tissue stress networks in obesity
Prof. Assaf RUDICH
Ben Gurion University, Israel
What molecularly defines human adipose tissue as “pathogenic”, differentiating metabolically-at-risk obesity from obesity with relatively low health risk, is still largely unknown. This talk will summarize our discovery of stress-related network that defines “pathogenic” human adipose tissue. This network consists of a MAP kinase signaling cascade, and of adipose tissue autophagy, which we propose to be co-regulated by a E2F1, a cell-cycle transcription factor that appears in post-mitotic adipocytes to regulate non cell-cycle pathways. Studies will also propose mechanisms linking this adipose tissue stress response to whole-body metabolic dysfunction.
Assaf Rudich is a Professor of Clinical Biochemistry and Pharmacology at Ben-Gurion University, Beer-Sheva, Israel. After Medical School and Medical Internship, he completed a PhD (1999) under the supervision of Prof. Nava Bashan on whether ROS and oxidative stress are causal factors in insulin resistance. His post-doctoral training at the Hospital for Sick Children in Toronto, Canada, under the supervision of Prof. Amira Klip, investigated temporal-spatial organization of the insulin signaling network. As a PI (since 2004) Prof. Rudich’s research focuses on mechanisms governing the contribution of different adipose tissues to obesity-associated cardiometabolic morbidity.
1:45pm – 2:30pm
Could lifestyle interventions differentially affect human adipose tissue dynamics?
Prof. Iris SHAI
Ben Gurion University, Israel
Currently, there are no definite guidelines, beyond overall weight loss, for decreasing organ-specific fat depots. In the CENTRAL trial we addressed the effect of specific lifestyle interventions on dynamics of MRI- assessed fat depots as abdominal sub-depots, hepatic, pericardial, pancreatic, renal and intermuscular fats. Is it all about body weight?
Iris Shai is a Professor of Nutrition and Epidemiology of chronic diseases at BGU, Israel. Following her fellowship at the Harvard School of Public Health, her focuses are long-term, compressive dietary RCTs and cohorts in the field of nutrition and cardio-metabolic risk. Prof. Shai performed the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) and 4-year follow-up, comparing the effects of low-fat, Mediterranean and low-carb diets on cardiometabolic risk and plaque regression, and the 2-year CArdiovasCulAr Diabetes & Ethanol (CASCADE) Trial, addressing the effects of red and white wine in type 2 diabetes. Her current trial questions the trajectory of human specific fat depots and fuel metabolism across dietary strategies.
Room 616, Faculté Pierre-et-Marie-Curie, 91 boulevard de l’Hôpital, 75013 Paris.
The flyer of the seminar is available for download.